Natagora, trained in France by Pascal Bary, justified 11-4 favouritism in the One Thousand Guineas at Newmarket.
The grey filly - by the Japanese sire Divine Light - was ridden by Christophe Lemaire and was tackling a mile for the first time.
But any stamina concerns surrounding her bid for the Newmarket Group One were firmly dispelled as she dug deep to repel the late challenge of Spacious by half a length.
Saoirse Abu took third, the same distance away, after making up acres of ground in the dash for the line.
Natagora was supplying Chantilly-based Bary - who landed Newmarket's Cheveley Park Stakes last year with Natagora - with handsome compensation after his hotly fancied Six Perfections had narrowly missed out to Russian Rhythm after a nightmare run in 2003.
On that occasion, it was Bary's runner who encountered traffic problems before storming home just too late.
"Natagora has done something fantastic. They all came to her, but she ran to the end," Bary said.
"She is a fantastic filly. I have dreamed about this since last October.
"She is very brave and she moves very well. Even when she is in front she doesn't pull or anything like that."
Lemaire for his part was similarly elated.
"I can't believe it," the French rider said.
"I had so much confidence, the only thing for me was to try to get a good position without using too much energy.
"She gave all she had and is a fantastic filly."
Natagora became the 15th French-trained winner of the fillies classic, following such Gallic luminaries of the turf as Miesque and Hatoof, with Taj Mah securing the first cross-channel success back in 1929.
Of the placed horses, Spacious' jockey Jamie Spencer thought she could have done with a stronger pace, and the James Fanshawe inmate will stick to a mile for the time being, rather than being upped in trip for a stab at the Oaks.
The latter event, may, however, be on the agenda for the Jim Bolger trained pair of Saoirse Abu and Lush Lashes, who came home better than most to finish sixth.
"I am very happy as both their jockeys said they wanted farther," said the County Carlow handler.
Getaway, meanwhile, confirmed he is the one to watch in the next few months when landing the Jockey Club Stakes.
Fourth in last year's Prix de l'Arc de Triomphe, Andre Fabre's charge will once again mix in only the highest circles.
"He has trained on a lot from four to five and will improve for this run. The Coronation Cup, the King George and the Arc will be his main targets," said Fabre.
"We will go where all the big races are."
Runner-up Sixties Icon ran well enough to suggest the ability that carried him to success in the 2006 St Leger hasn't totally gone out the window.
"I wouldn't say he's back to his best, but we do know we've got him back after two disappointing runs last year," said trainer Jeremy Noseda. "He'll no doubt come on for this, but we know for sure all the work we've done seems to have paid off."